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PhDs (f/m/d) within major EU-funded project - bone and diabetes research
Universitätsklinikum Carl Gustav Carus Dresden
Call for PhDs within major EU-funded project – 14 ESR projects for next-generation bone and diabetes researchers within the MSCA ITN FIDELIO
FIDELIO (Training network for research into bone Fragility In Diabetes in Europe – towards a personaLised medIcine approach), coordinated by Prof. Lorenz Hofbauer of TU Dresden, is an European Training Network, funded by the European Union Horizon 2020 programme. FIDELIO will train Early Stage Researchers (ESRs) to tackle the challenges of diabetic bone disease.
FIDELIO will address different aspects of diabetic bone disease from the perspective of epidemiology, genetics, miRNAs, microbiome, bone biology, biomechanics and clinical research. It will utilise advanced imaging and computational approaches, diabetes mouse models and access to clinical cohorts and registry data to obtain a comprehensive overview of how diabetes increases fracture risk.
Each ESR will be enrolled in a PhD programme to study for a doctorate and will conduct her/his own individual research project. The 14 ESR projects will comprehensively unravel the genetic and environmental mechanisms that contributes to bone fragility in diabetes, identify predictors and clinical markers for patient stratification, decipher the underlying molecular mechanisms of bone fragility in diabetes, and establish potential interventions through a personalised medicine approach.
The FIDELIO training programme is designed to address a translational gap that is currently a bottle-neck to advancing Precision Medicine. Interdisciplinary training and implementation of innovative approaches are the key. The training programme and experience of different international research environments cuts across traditional data and life sciences silos. The emphasis on translational research will support new collaborations between academia, the (bio)technology and health sector.
To achieve this paradigm shift in research training, FIDELIO brings together international leaders, including bone biologists, clinicians, epidemiologists, geneticists, engineers and entrepreneurs, from academia and industry. These experts are ideally positioned to develop the FIDELIO training programme and deliver a highly-trained workforce of next generation scientists, with the right mind-set, knowledge and skills, at the interface of Translational and Personalised Medicine.
We have 14 ESR projects available:
ESR1: Investigating the role of Wnt signalling in type 2 diabetes induced bone disease; Host: Technische Universitaet Dresden, Germany; Main supervisor: Professor Lorenz Hofbauer.
ESR2: Role of Dkk-1 in type 1 diabetes bone fragility, Host: Technische Universitaet Dresden, Germany; Main supervisor: Professor Martina Rauner.
ESR3: Investigation of effects of FEHC diet on bone health and fracture risk in T2D, Host: Università Campus Bio Medico di Roma, Italy; Main supervisor: Professor Nicola Napoli.
ESR4: Epidemiology of fragility fractures and diabetes; Host: Syddansk Universitet, Odense, Denmark; Main supervisor: Dr. Morten Frost.
ESR5: Bioenergetics of human osteoblasts, Host: Syddansk Universitet, Odense, Denmark; Main supervisor: Professor Moustapha Kassem.
ESR6: Development of diabetes-sensitive computational models of bone strength for the clinical diagnosis and pre-clinical tracking of diabetic bone fragility, Host: Universitaetsklinikum Hamburg- Eppendorf, Hamburg, Germany; Main supervisor: Professor Björn Busse.
ESR7: Investigating the role of osteocyte and mechanotransduction on bone fragility in type 2 diabetes, Host: Université de Geneve, Switzerland. Main supervisor: Professor Serge Ferrari.
ESR8: Mechanoregulation of bone remodelling in type 2 diabetes using HRpQCT in vivo patient data, Host: Eidgenoessische Technische Hochschule Zuerich, Switzerland; Main supervisor: Professor Ralph Müller.
ESR9: Role of microRNA in diabetic bone disease, Host: The University of Sheffield, United Kingdom; Main supervisor: Professor Richard Eastell.
ESR10: Genetics and biologic pathways underlying fracture risk in type 2 diabetes, Host: Erasmus Universitair Medisch Centrum Rotterdam, Netherlands; Main supervisor: Dr. Ling Oei.
ESR11: Metformin effects on the diabetic bone and the interaction with the gut microbiome, Erasmus Universitair Medisch Centrum Rotterdam, Netherlands; Main supervisor: Dr. Carolina Medina-Gomez.
ESR12: Bone matrix characterization and analysis of AGE accumulation in diabetic bone, Universitaetslinikum Hamburg-Eppendorf, Hamburg, Germany; Main supervisor: Dr. Katharina Jähn.
ESR13: miR-203a functions as regulator of type-2 diabetic bone disease, TamiRNA GmbH, Vienna, Austria; Main supervisor: Dr. Matthias Hackl.
ESR14: Exploring subgroups to inform personalized treatment strategies, Host: Eidegenoessische Technische Hochschule Zuerich, Switzerland; Main supervisor: Professor Andrea Burden.
Applicants can apply for up to two different ESR projects. However, please apply separately for each position.
ESR shall at the date of recruitment by the host organisation be in the first four years (full-time equivalent research experience) of their research careers and have not been awarded a scientific doctoral degree.
Applicants can be of any nationality.
Applicants must have an ability to understand and express themselves in both written and spoken English to a level that is sufficiently high for them to derive the full benefit from the network training (typically IELTS min. 7, TOEFL internet-based min. 90 or similar level as proven by other tests).
Applicants must be eligible to enrol in a PhD programme at the host institution (or at a designated university in case the host institution is a non-academic organisation).
In addition: H2020 MSCA Mobility Rule: researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of the host organisation for more than 12 months in the 3 years immediately before the recruitment date. Compulsory national service, short stays, such as holidays and time spent as part of a procedure for obtaining refugee status, are not taken into account. Eligible researchers must not have spent more than 12 months in the 3 years immediately prior to the date of selection in the same appointing international organisation.
H2020 MSCA eligibility criteria: Early Stage Researchers (ESRs) must, at the date of recruitment by the host organisation, be in the first four years (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree. Full-time Equivalent Research Experience is measured from the date when the researcher obtained the degree entitling him/her to embark on a doctorate (either in the country in which the degree was obtained or in the country in which the researcher is recruited, even if a doctorate was never started or envisaged).
Secondments and training:
ALL ESRs are required to visit several other FIDELIO partners on secondments of 1-3 months duration, and attend summer schools and training courses organized by various FIDELIO partners.
You will be employed by the host organisation for 36 months.
You will receive a competitive salary plus allowances. Moreover, funding is provided for technical and transferable skills training and participation in international conferences.
You will interact with an international research consortium of over > 25 researchers
You will develop scientific and transferable skills through the personalised training offered by the host organisation and your individual research project, and the network-level training programme
You will be supervised by recognized experts and have access to (beyond) state-of-the-art research and infrastructure.
You will participate in secondments to FIDELIO partners for trans- and interdisciplinary research training.
You will participate in outreach activities targeted at a wide audience.
You will interact with the other members of this international consortium and will benefit from the joint training platform to develop specialised and diverse skills
Please, find additional information in the Information package for Marie Curie fellows.
All applicants are required to provide the following documentation:
Motivational letter (one page max.), stating a) your reasons for wanting to become a part of FIDELIO and for applying for the specific position you chose, b) why you consider yourself to be a suitable candidate for this position
A detailed CV, including: date and place of birth, private address, previous countries of residence within the last 3 years, education and work experience, scientific and language skills, publications, any other relevant skills or activities as well as the name and contact details of up to three referees
Certificates of your BSc and/or MSc degrees (transcribed into English)
Certificates pertaining further skills relevant to the position you are applying for (e.g. animal experimentation training course, technical skills training, etc.)
An abstract of your Master thesis (If you are applying for a position in the UK and you do not have a MSc degree, please provide an abstract of your Bachelor thesis)
English language certificate(s), if English is not your first language
Most recent school leaving certificate (e. g. university-entrance diploma, GCSE, Matura, vocational school degree, etc.)
Please also mind the specific requirements of each position/host.
Please note that these job opportunities are for Early Stage Researchers (ESR) only, as defined under "Specific Requirements" above.
We therefore kindly ask you to check your eligibility very carefully, as we cannot consider applicants who do not meet these requirements.
Participating Universities/Non-academic organisations:
Technische Universitaet Dresden, Germany
Università Campus Bio Medico di Roma, Italy
Syddansk Universitet, Odense, Denmark
Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Germany
Université de Geneve, Switzerland
Eidgenoessische Technische Hochschule Zuerich, Switzerland
The University of Sheffield, United Kingdom
Erasmus Universitair Medisch Centrum Rotterdam, Netherlands
TamiRNA GmbH, Vienna, Austria Additional partner organisations that will support FIDELIO training activities:
SCANCO Medical AG, Switzerland
IBM Research GmbH, Switzerland
Qiagen GmbH, Germany
Philips GmbH, Germany
STENO Diabetes Center North Denmark, Denmark
BOKU – University of Natural Resources and Life Sciences, Vienna, Austria Additional Information:
We in the FIDELIO consortium value diversity and we commit to equal treatment of all applicants irrespective of gender, sexuality, health status as well as social, cultural or religious background.
5 September 2019: Launch of 14 ESR position job advertisements
21 October 2019: Deadline for online application process
22 October 2019: Circulation of received applications to supervisors
28 October-1 November 2019: Evaluation of applications by supervisors including Skype interviews
04 November 2019: Invitation of two shortlisted candidates per ESR position to recruitment event 25 November 2019: Recruitment event in Rome, Italy
January 2020: Expected start date
Medizinische Fakultät Carl Gustav Carus der TU Dresden
Fetscherstraße 74, 01307 Dresden, Germany
Please apply online at https://www.fidelio-project.eu/fellows