PhD students (f/m/d) study of inflammation-associated pathways in intestinal and liver cancer
Technische Universität Dresden / Universitätsklinikum Carl Gustav Carus Dresden
The group of Prof. Sebastian Zeissig at the Center for Regenerative Therapies Dresden (CRTD) is seeking
2 PhD students (E13 / 65 %)
for the study of inflammation-associated pathways in intestinal and liver cancer.
Our group is interested in the crosstalk between inflammation and carcinogenesis in the intestine and the liver. Research follows a translational strategy in which human observations are mechanistically dissected using mouse models, primary human tissues and cell culture approaches. Research is conducted at the Center for Regenerative Therapies Dresden (CRTD). For more information about the research of our group, please refer to: https://www.crt-dresden.de/research/research-groups/core-groups/crtd-core-groups/zeissig-mucosal-immunology/
In your project, you will investigate how inflammatory signaling influences carcinogenesis in the intestine (PhD student 1) and the liver (PhD student 2), with particular emphasis on the pathway of calcineurin and nuclear factor of activated T cells (NFAT) and its microbiota-dependent activation. Studies will be based on in vivo mouse models of colorectal and hepatocellular carcinoma using genetically engineered mice. Mechanistic studies will be conducted using cell lines in vitro and human cancer tissues ex vivo. Both projects are highly translational and address questions relevant to human cancer biology, with the long-term goal of developing new strategies for cancer treatment.
Candidates should hold a Master degree (or equivalent) in a field related to the described projects. Expertise in the handling of mice, in cell culture and in basic methods in molecular biology (PCR, western blot) and histology are desired.
Duration, salary, conditions
Payment is according to E13 (65 %). Two positions are offered for 3 years each. PhD students will be enrolled in the Bioscience PhD Students (BiPS) program.
Applicants are asked to send one PDF-file containing:
1. Cover letter
2. Curriculum vitae with list of publications
3. Copies of academic degrees and transcripts of records
4. Contact information for at least one letter of recommendation