PhD Student in Immunology/Cell Biology (f/m/x)

Our group works on intramembrane proteolysis which links protein degradation with signal transduction and thus represents an important regulatory mechanism for cellular homeostasis. We are especially interested in the SPP/SPPL family of intramembrane proteases. One member of this protease family, SPPL2a, is of crucial importance for development and function of B cells and dendritic cells in mice. Recently, also human patients with SPPL2a deficiency were identified to lack certain dendritic cells and to be susceptible to mycobacterial infections. These phenotypes have been linked with a the SPPL2a substrate CD74 which accumulates in the absence of the protease. However, we recently found that also other members of the SPP/SPPL protease family impact on immune cells via additional, currently unpublished substrates. At the Institute of Physiological Chemistry of the TU Dresden in the group of Prof. Dr. Bernd Schröder we are looking for a highly motivated

PhD Student in Immunology/Cell Biology (f/m/x)

In the planned PhD project, we want to further characterize the impact of SPP/SPPL proteases on immune cell development and function in more detail. Therefore, the PhD project will combine basic biochemical/cell biological approaches with the extensive analysis of primary immune cells from our different mouse models. The project offers a broad spectrum of experimental techniques and is at the interface of answering fundamental cell biological/immunological questions in conjunction with characterizing in the underlying mechanism in certain human diseases. For further information please click here.

• Schneppenheim et al. & Schröder, J Exp. Med 2013
• Mentrup et al. & Schröder, Cell Mol Life Sci 2020
• Mentrup et al. & Schröder, Nat Comm 2022

The position funded by the Deutsche Forschungsgemeinschaft (DFG) is available from 01.09.2022 or later. We kindly ask you to apply via our online form to make the selection process faster and more effective. Your Profile:

• You hold a Masters degree in biochemistry, biology or related subjects
• You have experimental experience in one of the following areas: immunology, molecular biology, biochemistry, cell biology
• You are a great team worker
• You enjoy studying fundamental questions in biology and doing science

We offer:

• An exciting research project with high translational relevance
• Ability to learn and apply a broad spectrum of methods from biochemistry, cell biology and immunology
• Integration into a highly motivated team in a well-equipped Institute.

Application of women is appreciated. Disabled persons with equal qualification will be preferred. We kindly ask you to apply preferably via our online form to make the selection process faster and more effective. Of course, we also consider your written application without any disadvantages. We look forward to receiving your application until July 31st, 2023 online with registration number PCH0923767.