At the next possible Point of Start we are looking for a highly motivated

Postdoctoral scientist / PhD student (f/m/x)

These full time positions are initially for 36 months with a possibility for extension.

A postdoctoral position and a PhD student position are immediately available in the area of genome stability in themammalian germline in the lab of Attila Toth. The Toth lab is at the Technische Universität Dresden, which is one the few Elite Universities in Germany, featuring a life sciences focus area, and a highly international and collaborative researchcommunity. The Toth group strives to uncover the molecular mechanisms of chromosome biology that ensure safetransmission of genetic information to the germline. Generation of haploid gametes from diploid germ cells by meiosis isthe hallmark of sexually-reproducing organisms. Orderly halving of chromosome numbers poses unique challenges whichrequire meiosis-specific features of chromosome biology.

One of the key features of meiosis is a modified homologous recombination that initiates with the generation of potentiallygenotoxic DNA breaks. Careful regulation of meiotic recombination initiation is pivotal for the generation of gametes withhealthy genomes, yet, the understanding of the underlying mechanisms is sketchy. This ambitious project will explore theprinciples that control spatiotemporal dynamics of meiotic recombination initiation in mice. We will combine advancedchromatin analysis, cytology and large scale sequencing technologies. Further, the project involves a close cooperationwith physicists / bioinformaticians in the campus to develop quantitative models for recombination. Relevant articles ofthe lab, doi:10.1093/nar/gkab082. doi: 10.1016/j.molcel.2019.03.022. doi: 10.1038/ncb3417. doi: 10.1038/ncb2213

Your profile:

• We are seeking scientists with experience in molecular and cellular biology. Skills in chromosome and genome biology, e.g. ChIP-seq, CUT&RUN, ATAC-seq or similar are advantageous.

We offer you:

• Flexible and family-friendly working hours
• Care of your children through partnerships with children's institutions near the University Hospital
• Use of company prevention offers including courses and fitness in our Carus Vital health centre
• Taking part in job-oriented educational course in our Carus Akademie
• Use of our job ticket for public transport in Dresden and the surrounding area
• A position according to the TV-L conditions (E13)
• Job-oriented further and advanced training with individual planning of your professional Career
• A Position according to TV-L conditions (E13 / 65%)

A detailed CV (with publications, if available), cover letter and references should be provided. Application of women isappreciated. Disabled persons with equal qualification will be preferred.

We kindly ask you to apply preferably via our online form to make the selection process faster and more effective. Ofcourse, we also consider your written application without any disadvantages.

We look forward to receiving your application until 31st October 2021 online with Registration number PCH0921732. Forfurther Information please contact Prof. Attila Tóth by telephone 0351-458-6467 or by E-Mail: attila.toth@tu-dresden.de