PhD student position (f/m/d) in pharmacology and molecular biology
University Medical Center Göttingen
The Institute of Clinical Pharmacology at the University Medical Center Göttingen
invites applications for
PhD student position
(m/f/d) in pharmacology
and molecular biology
for 3 years, part time (25h/week) | salary according
The University Medical Center Göttingen is a tertiary care center and offers great
development potential. Its 7,900 employees work in over 65 departments and
facilities to provide top-quality patient care, excellent research and modern
teaching. Göttingen, "City of Science", located near the center of Germany, the
University Medical Center Göttingen is embedded in the city's attractive network of
scientific research facilities.
The Institute of Clinical Pharmacology is conducting research on new and
established drugs with a focus on the evaluation of drug effects, efficacy, safety,
and tolerability. The aim of our research activity is to identify and optimise
personalised therapy options tailored to individual patients or patient groups. To
this end, interdisciplinary medical expertise is combined with methodological
excellence to gain new knowledge for important medical indication areas.
Our methodological approaches include mainly:
molecular and cell biology, in vitro assays, genotyping
clinical studies of drugs involving patients and healthy volunteers
pharmaceutical analytics in biological samples
The Institute of Clinical Pharmacology is working towards more efficient and safer
drug therapies for patients to improve health and well-being.
Almost a third of drugs currently on the market constitute racemic mixtures and
stereoisomers can differ significantly in their therapeutic and adverse effects.
The aim of this project is to contribute to a more comprehensive knowledge of
stereoselective recognition of substrates and inhibitors by drug membrane
transporters. The focus will be on organic anion and organic cation transporters of
the solute carrier family that mediate uptake of drugs into the liver and kidneys for
metabolism and elimination. We are particularly interested in transport proteins that
show pronounced differences in their activity due to genetic variation with the
overall aim to enable a more precise individualisation of drug therapy.
Stereospecificity will be studied in clinically relevant combinations of transporters
and substrates or inhibitors using in vitro assays and HPLC-MS/MS analyses. Cell
lines recombinantly expressing these transporters will be created using molecular
biological techniques. Altogether, this project will contribute to the development of
more effective and safe drugs as well as in individualised therapy.
very good to excellent university degree (Masters, State Exam, Diploma or similar) in Molecular Medicine, Molecular Biology, Biochemistry, Biology, Biotechnology, Pharmacy or a related field
advantageous but not a requirement is practical experience in molecular biology, in vitro assays or HPLC-MS analytics
high intrinsic motivation and commitment
ability to work independently as well as in a team perseverance and flexibility
English language proficiency
interdisciplinary scientific environment
a friendly and welcoming work environment
international networking possibilities
competitive salary according to 65 % TV-L for 3 years
We look forward to receiving your application by April 30th, 2020:
Institut für Klinische Pharmakologie
Dr. Muhammad Rafehi
Please send your application via E-mail in PDF-format or via
mail in copy and not in folders.
Travel and application fees cannot be refunded or