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SKELETAL CELL METABOLISM IN BONE PATHOLOGY AND REGENERATION

(ref. BAP-2018-173)

Employment percentage: Full-time
Location: Leuven
Apply before: Thursday, June 28, 2018

The laboratory of professor Geert Carmeliet is focusing on skeletal cell metabolism in bone development, homeostasis and disease. The lab is looking for a dynamic, highly motivated postdoctoral researcher to join the team. The growth of blood vessels, or angiogenesis, is critical for normal bone development and plays a crucial role in bone repair. Hypoxia signaling is an important stimulator of angiogenesis, but also regulates skeletal cell properties by controlling their metabolism. Our recent data show that cell metabolism of skeletal cells contributes to bone development and is crucial for bone regeneration. These studies reveal that targeting skeletal cell metabolism could be a possible therapeutic strategy for targeting bone disorders. We are now aiming to investigate several metabolic pathways in different skeletal cell types. Advanced metabolic analyses will be combined with state-of-the-art cell biological and molecular assays. The importance of the identified metabolic pathways will be validated by genetic or pharmacological approaches in in vitro models and in preclinical mouse models of bone pathology.

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Responsibilities
  • You can work independently within a multidisciplinary team
  • You contribute to projects by analyzing the metabolic profile of skeletal cells using appropriate methodology
  • You can use preclinical mouse models to provide in vivo significance of the metabolic pathways
  • You can combine wet- and dry-lab expertise in molecular and cellular biology to answer specific research questions
  • You can organize and troubleshoot practical work independently
  • You can communicate results in a professional manner and participate in seminars.
Profile
  • You have a PhD in biomedical sciences with focus on metabolism/skeletal tissue/regenerative medicine or any related field.
  • You should be skilled in molecular and cellular biology methods, biochemistry and cell culture.
  • You are interested in working in a multidisciplinary environment of experts in biomedical sciences and engineering.
  • You have passion for science and the motivation to work on an innovative project in an open and dynamic team.
  • You should have excellent organizational skills and can work in a team as well as independently.
  • You should have good social and communicative skills and a solid knowledge of English.
  • You have a good publication record in peer-reviewed international journals.
Offer
We offer:
  • a full-time position in a young and dynamic team;
  • the opportunity to work in a multidisciplinary environment;
  • access to state-of-the art technologies in biomedical research;
  • a dynamic working environment in which quality, professionalism and team spirit are encouraged;
  • excellent training conditions within a team of experts.
Interested?
For more information please contact Prof. Dr. Geert Carmeliet, mail: geert.carmeliet@kuleuven.be. Your application file should contain complete CV, motivation letter, list of publications, summary of past research and contact information or reference letter of 2 or 3 referees.

You can apply for this job no later than June 28, 2018 via the online application tool

KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.

Closing date: 28.06.2018
Closing date: 28 June 2018 Erschienen auf academics.de am 15.05.2018
In your application, please refer to academics.com