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University of Göttingen
Universitätsmedizin Göttingen
The Section of Molecular Developmental Genetics at the Institute of Human Genetics, University of Göttingen, currently offers a
PhD student position
for 3 years, part time 65 % | salary according to TV-L
The University Medical Center Göttingen is a tertiary care center and offers great development potential. Its 7,400 employees work in over 65 departments and facilities to provide top-quality patient care, excellent research and modern teaching. Göttingen, "City of Science", lies near the center of Germany, the University Medical Center Göttingen is embedded in the city‘s attractive network of scientific research facilities.
The PhD student will be involved in the project "Hedgehog signaling in the adult pituitary gland and in pituitary adenoma formation". The project is funded by the Deutsche Forschungsgemeinschaft e. V. The project can be started in February 2017.
The Hedgehog (HH) signaling pathway plays a crucial role during the development of the pituitary gland which represents a gland with superior function in the neuroendocrine system. We recently showed that activation of HH signaling results in enhanced proliferation of adult Sox2+ and Sox9+ pituitary stem cells and in elevated expression of pituitary hormones (Acth (adrenocorticotropic hormon), Gh (growth hormone), Prl (prolaktin). Together with our findings that human pituitary adenoma show excess activation of the HH signaling cascade these data might open new possibilities for novel targeted therapies against hormone-producing adenoma and associated diseases (e.g. Morbus Cushing, acromegaly and hyperprolactinemia). The current project aims to validate the role of HH signalling in the homoeostasis of the adult pituitary gland and in pituitary adenoma formation. Therefore mouse models for lineage tracing of Gli1 expressing pituitary cells and for the conditional overactivation of HH signaling in the adult pituitary gland will be generated. Additionally human pituitary adenoma cultures it will be used to analyze if the overactivation of the HH signaling pathway is indeed involved in the formation and/or hormone production of PA and thereby might be the target for targeted therapies.
Qualifications and experience:
  • you hold a master or diploma degree in natural science
  • you have experience with cell culture techniques and with methods used in molecular biology
  • experience with murine (tumor) models and flow cytometry will be advantageous
  • you are interested in aspects of signal transduction, tumor genetics and the development of new tumor therapies
  • you have good IT and communication skills in English
  • you are team and goal-oriented
Please send an electronic form of your application including CV; certificate of school education, diploma, master etc.; description of your lab experience; short abstract of your master or diploma work and
contact details of two references until the 15th of January 2017.
University Medical Center Göttingen
Institute of Human Genetics
Dr. rer. nat. Anja Uhmann
Section of Molecular Developmental Genetics
at the Institute of Human Genetics

37099 Göttingen
Tel.: +49 551/39-14100
Fax: +49 551/39-66580
E-Mail: auhmann@gwdg.de
Web: http://www.humangenetik.gwdg.de
Travel and application fees cannot be refunded or transferred.
Men are especially encouraged to apply. Applicants with disabilities and equal qualifications will be given preferential treatment.

Closing date: 15.01.2017
Closing date: 15 January 2017 Published on academics.com on date 15 November 2016
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