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Stop diabetes with insulin tablets

Could a capsule of insulin crystals a day stop the development of type 1 diabetes? There are indications that this could be the case. In the international TrialNet study*, which follows relatives of individuals with type 1 diabetes, researchers are investigating whether oral insulin could prevent or delay the disease.

Type 1 diabetes is the autoimmune form of diabetes, in which the patients' insulin-producing beta cells are destroyed by their own immune system. "We know that if a person has two autoantibodies and one of them is against insulin, there is a 50 per cent risk that they will develop type 1 diabetes within five years. It doesn't matter how old you are", says Äke Lernmark, Professor of Experimental Diabetes Research at Lund University in Sweden.

"There are indications that oral insulin may prevent or delay the clinical onset of type 1 diabetes among individuals with autoantibodies against insulin, who are thus in the risk zone", says Äke Lernmark, who will be initiating and coordinating the Swedish TrialNet study.

Äke Lernmark refers to a study presented earlier in the year by American and Canadian researchers. In the study, which ran from 1994 to 2003, participants with relatives who had type 1 diabetes and at least two autoantibodies, one of which against insulin, took either oral insulin or placebo capsules containing an inactive substance. At first, the results were a disappointment. Just as many people in the treatment group became ill as in the placebo group.

"However, the subsequent analyses showed something different. Among those who had high levels of insulin autoantibodies at the start of the study, the oral insulin had an effect and the development of type 1 diabetes was delayed. The delaying effect lasted for as long as the participants took the insulin", says Äke Lernmark, adding that those who are now being recruited for the Swedish TrialNet study with oral insulin also have high levels of autoantibodies against insulin.

No one knows how oral insulin might stop type 1 diabetes. However, Äke Lernmark believes a possible explanation could be that the immune system becomes accustomed to the low daily doses of insulin in the gastrointestinal tract. The insulin is not perceived as a foreign substance to be rejected by the immune system.

This line of reasoning is the same as for desensitisation for allergies, in which the dose of the substance that provokes the allergy is gradually increased. The oral insulin study will run for several years and is open to all those who meet the requirements and are aged between 3 and 45.

*TrialNet TrialNet is an international network of researchers who study the development, prevention and early treatment of type 1 diabetes. A total of 18 clinics in the USA, Canada, Europe and Australia are involved. In Sweden, the study is coordinated from the Lund University Diabetes Centre in Malmö. The study is funded by the National Institutes of Health in Maryland, USA.

Contact: Äke Lernmark, Professor of Experimental Diabetes Research at Lund University Diabetes Centre in Malmö. Tel: +46 40 39 19 01, mobile: +46 706 16 47 79

idw :: 19.09.2012

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