Our mission as interdisciplinary, international, research group “Clinical Pharmacy & Biochemistry” led by Prof. Charlotte Kloft at the Institute of Pharmacy, Freie Universität Berlin is applying high scientific standards and innovative methodologies with the ultimate aim to foster the rational use of medicines while empowering young scientists to perform clinically relevant research (
Our research area, pharmacometrics and systems biology, is situated within a transdisciplinary field and combines experimental and theoretical concepts. Our research is based on two research pillars: (1) Bioanalysis, microdialysis, cell culture, and (2) Pharmacometric (data) analysis. As a key feature, we constantly bridge these two pillars. Our pharmacometric projects are based on in vitro and/or in vivo data obtained by experimental research, while innovative dynamic in vitro systems utilise modelling and simulation approaches for optimising experimental design. In addition, many of our projects are realised as parts of clinical studies. Typically, our research is collaborative and embedded in consortia at a national and international level (EU, global).
Scientific work as a part of the GlobalResist project, a research consortium of partners at Freie Universität Berlin, Charité-Universitätsmedizin Berlin, Technische Universität Berlin and funded by the Berlin University Alliance. GlobalResist aims to forecast antibiotic resistance evolution as a novel approach to address a major issue in global health. Development of resistance to antimicrobial agents is one of the major challenges in the fight against infectious diseases. The work is centred on forecasting antibiotic resistance evolution by applying innovative translational modelling and simulation techniques and/or in vitro infection models, incl. publication of the results.
Participation in guiding doctoral students as well as general scientific tasks in research and research organisation. The activity serves scientific qualification. Participation in teaching.
- University degree in Pharmaceutical or Life sciences or related field
- Qualified PhD in pharmacometrics, systems pharmacology, or infection models, preferentially PK/PD modelling of antimicrobials or antimicrobial resistance evolution.
In-depth experience in organisation and performance of research projects and in scientific publication in the area of pharmacometrics or anti-infectives.
Theoretical and practical experience in the field of pharmacometric modeling & simulation of antimicrobial therapy and resistance development and/or in vitro infection models. Additionally, experience in either (i) evaluating pharmacokinetic, pharmacodynamic or systems pharmacology data and pharmacometric analysis with NONMEM, R or similar pharmacometric software, (ii) Bayesian analysis using STAN (or similar platforms) or bioinformatics, or (iii) one of our experimental platforms (LC/MS-MS, microdialysis, bacterial infection models, in vitro metabolism) is required; Publication in the field of clinical pharmacy/pharmacometrics/anti-infectives. High intrinsic motivation/high level of commitment and an excellent team player. Strong verbal/written communication skills and excellent English language skills.
Applications should be sent by e-mail, together with significant documents, indicating the reference code,
in PDF format (preferably as one
document) no later than April 24th, 2023
to Mrs. Prof. Dr. Charlotte Kloft:
or postal to
Freie Universität Berlin
Fachbereich Biologie, Chemie, Pharmazie
Institut für Pharmazie Klinische Pharmazie
Frau Prof. Dr. Charlotte Kloft
D-12169 Berlin (Steglitz)
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