Postdoctoral Research Scientist (f/m/d) on human pluripotent stem cells for mitochondrial medicine
Location: Heinrich Heine
University (HHU), Medical Faculty, Dusseldorf, Germany Salary: EG13-100% Duration: to the 31.05.2024 Starting date: 1st October 2021 Application deadline: 31st July 2021
Postdoctoral Research Scientist on human pluripotent stem cells for mitochondrial medicine
The employment is limited to the 31.05.2024 until the end of the project (Wissenschaftszeitvertragsgesetz – WissZeitVG § 2 Absatz 2).
A Postdoctoral Research Scientist position is available at the
Medical Faculty of Heinrich Heine University (HHU) in the laboratory
of Stem Cell Metabolism led by Prof. Alessandro Prigione, to
work on the European Joint Programme for Rare Diseases
(EJPRD) Project “CureMILS”.
CureMILS is a new European Consortium coordinated by Prof. Prigione involving seven countries (Germany, Netherlands, Italy, Luxemburg, Poland, Finland, and Austria). The Consortium aims to apply reprogramming-driven drug discovery for the rare neurological disease MILS (mitochondrial DNA-associated Leigh syndrome).
The Prigione laboratory focuses on the use human induced
pluripotent stem cells (iPSCs) for modeling neurological disorders
affecting mitochondrial function (Lorenz et al, Cell Stem Cell
2017; Inak et al, Nature Communications 2021). We combine
neuronal differentiation and brain organoids with
mitochondrial-centered high-content microcopy for drug discovery
(Brunetti et al, Stem Cells 2021; Cunnane et al, Nature
Review Drug Discovery 2020).
We are looking for a highly motivated and creative candidate with a PhD (or be close to completion) and previous experience in stem cell biology and genome engineering. A proven track record and the ability to perform collaborative work in a team are essential. Additional knowledge in neuroscience, mitochondrial biology, and organoid differentiation is desirable.
The successful candidate will interact with the members of the CureMILS Consortium. She/he will perform cutting-edge research using patient-derived induced pluripotent stem cells (iPSCs), genome editing (CRISPR/Cas9 and base editing), generation of neuronal cells and brain organoids, and high-content analysis-based screenings using libraries of repurposable drugs.
HHU is a modern German University campus with excellent reputation due to the high number of collaborative research centers. Dusseldorf is the state capital of North Rhine-Westphalia, and provides an attractive environment ranked among the top cities worldwide in terms of high quality of life.
HHU is an equal opportunities employer. We welcome applications from non-binary or gender-queer applicants as well as person with disabilities or equal status.