The Max Planck Institute for Biophysical Chemistry is one of the largest institutes of the Max Planck Society for the Advancement of Science and conducts basic research to advance knowledge and benefit society. Innovative projects and interdisciplinary cooperation characterize research within the Max Planck Society.
The research group of Quantitative and Systems Biology (Juliane Liepe) invites applications for a position as
– Proteomics of Antigen Presentation –
(Code number 06-21)
The aim of this project is to generate proteomics and immunopeptidomics data from biological and animal models of measles infection and cancer cells treated with various therapy approaches, which will be used to develop a mechanistic multi-omics computational model of antigen processing and presentation (APP) pathway. This project is a cornerstone of a bigger project of Juliane Liepe “Integrative mechanistic and multi-omics Modelling of Antigen Presentation to predict epitope dynamics – IMAP” recently funded by the prestigious ERC Starting grant (ERC-StG) fund. The IMAP project will start on April 1st, 2021 and will finish on March 31st, 2026.
The postdoc will be based in the Quantitative and System Biology lab led by Juliane Liepe as well as the Bioanalytical Mass Spectrometry lab led by Prof. Henning Urlaub.
Liepe lab is a dynamic environment where computational biology leads, through international collaborations, a broad range of leading researchers in biology, molecular and structural biology, genomics and immunology, with the final goal of developing tools and knowledge with translational applications in cancer, infection and autoimmunity, such as: Liepe et al., Science 2016 and Blankenstein et al., patent PCT/EP2019/050027.
Urlaub lab is a leading mass spectrometry (MS) lab with expertise in method development, protein-protein and protein-ligand interactions, crosslinking MS, and quantitative proteomics including mapping of PTMs.
The candidate will work closely with computational biologists in Liepe lab and MS-based proteomics experts in the Urlaub lab as well as biologists, immunologists and oncologists, with the final objective of understanding the APP pathway with potential strong implication in personalized medicine. To do so, the candidate will develop and employ new proteomics approaches.
PhD or equivalent degree in either Chemistry, Biology or Biochemistry
strong background in proteomics and (quantitative) mass spectrometry
interest in crosslinking MS, signalling pathway, immune system, T cells, bioinformatics
The appointment is for two years and may start immediately. The payment and benefits are based on the TVöD guidelines.
The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.
Please send your application including a short letter of motivation, CV, a list of publications, and email addresses of two referees preferably via email as single PDF file with reference to the code number to email@example.com.
Max Planck Institute for Biophysical Chemistry
Research Group Quantitative and Systems Biology
Am Fassberg 11