1 job vacancy

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Chemistry Biochemistry Biology Biomedicine Food Science Medicine PhD Student Bavaria University Hospital

Doctoral Candidate (m/f/x) with a Master's Degree in Biology, Biochemistry, or Biomedicine

2023-11-14 Universitätsklinikum Würzburg Würzburg

Doctoral Candidate (m/f/x) with a Master's Degree in Biology, Biochemistry, or Biomedicine

Published: 2023-11-14
Application deadline: 2023-12-20
Part-time position
: Universitätsklinikum Würzburg
: Würzburg

The Chair of Endocrinology and Diabetology at the University Hospital of Würzburg (AG PD Dr. Dischinger) is looking for a

Doctoral Candidate (m/f/x) with a Master’s Degree in Biology, Biochemistry, or Biomedicine

starting at 1^st of January 2024 in full-time or part-time

This is what you can look forward to:

PhD at the Medical Faculty of the University of Würzburg in a collaborative project between Endocrinology and the Comprehensive Heart Failure Center
research on the “hottest topic in clinical endocrino-cardiology”, heart failure with preserved ejection fraction (HFpEF) at top international level
contacts to the Scientific-Champions-League
laboratories profoundly equipped with equipment and MLS personnel
interdisciplinary team with flat hierarchies and uncomplicated exchange of information
participation in international congresses
publications with high impact
opportunity to participate in the Graduate School of Life Science (http://www.graduateschools.uni-wuerzburg.de/life-sciences/)
our own day-care centre for children with extended opening hours (05:30 a.m. to 06:00 p.m.)
public service workplace

Your area of responsibility:

careful development of the research methodology
independent lab analysis of blood and heart samples obtained from animal experiments
statistical processing of the data (statistical consulting available)
writing your doctoral thesis and scientific publications
for more information on the research focus see below

Your profile:

master’s degree in biology, ecotrophology, biomedicine, or biochemistry
interest in translational research
previous experience with animal experiments (desired)

The position is funded by the German Research Foundation (DFG) at 65% for three years.

For further information on the working group see https://www.ukw.de/medizinische-klinik-i/endokrinologie/forschung/experimentelle-adipositasforschung/ or contact PD Dr. Ulrich Dischinger by phone at +49 931 201-39985 or by e-mail at dischinger_u@ukw.de.

Please send your CV / resume and any certificates or references as a PDF file by 20th of December 2023 to PD Dr. Ulrich Dischinger at dischinger_u@ukw.de.

The central research questions of the project are:

How can the HFpEF phenotype induced in the animal model be influenced by the substances used (especially GLP-1 analogues, SGLT-2 inhibitors) at the level of calcium handling / mitochondrial energetics?
What is the importance of liver function / health (mitochondria, histology, inflammasome) and the different adipose tissue depots?

Further information
The aim of this work is to further elucidate the pathophysiological relationships between obesity and heart failure with preserved ejection fraction (with special attention to mitochondrial energy production and calcium balance) and the analysis of drug therapy options in an established animal model (the animal experiment is already approved by the authorities). The topic combines endocrinology and cardiology in an innovative way and provides an excellent basis for further scientific work. It sheds light on established (GLP-1 analogues, SGLT-2 inhibitors) and experimental (PYY) treatment options for obesity. The aim is a comprehensive analysis of the heart by means of highly specific methods (Oroboros, Seahorse) on the one hand and other organs involved in the provision / processing of different energy carriers (liver, adipose tissue depots) on the other. All steps are well established in the participating institutions. The animal experimental approach allows a detailed and comprehensive analysis of cardiac function / energy as well as of a variety of other organs compromised in obesity. Animal experimental experience, which enables in-vivo analysis (e.g. echo), is optional but not a prerequisite.

1 job vacancy in the categories Chemistry Biochemistry Biology Biomedicine Food Science Medicine PhD Student Bavaria University Hospital